Invasive carcinoma NST (also known as invasive ductal carcinoma) This is the most common type of breast cancer, occurring in approximately 80% of cases and can occur in men as well as women. It is often described on a pathology report as NST (no special type) or NOS (not otherwise specified) as it doesn't have special distinguishing features In 2012 World Health Organization (WHO) classification , pleomorphic carcinoma is an uncommon variant of high-grade invasive carcinoma of no special type (NST) of breast characterized by proliferation of pleomorphic and bizarre tumor giant cells comprising >50% of the tumor cells in a background of adenocarcinoma or adenocarcinoma with spindle In addition, SPC in situ can also be accompanied by invasive disease, which can be in the form of invasive breast carcinoma of no special type or mucinous, tubular, lobular or mixed subtypes [69, 75]. Type A mucinous carcinoma with larger quantities of extracellular mucin represents the classic non-endocrine variety. Pure and mixed variants have been described . The most common admixture is with invasive carcinoma of no special type. A pure tumor must be composed of more than 90% mucinous carcinoma . The in situ component may have a The clinicopathological characteristics of the 231 patients with node-negative invasive carcinoma of no special type are summarized in Table 1. The mean age of the patients was 61.5 ± 12.6 years. The mean age of the patients was 61.5 ± 12.6 years. All cases were further classified into three groups: (1) invasive carcinomas of no special type with OGC (group 1: OGC-IC NST); (2) “mixed” cases, i.e., tumors composed of clearly distinct The most common type of invasive breast cancer is infiltrating ductal carcinoma (IDC), accounting for 70–80 % of all invasive breast cancers. Squamous cell carcinoma (SCC) of the skin overlying the breast is very rare tumor that is diagnosed when more than 90 % of the malignant cells are of the squamous type. The purpose of the present study was to investigate if the vimentin expression status might serve as a significant predictor of outcomes in patients with invasive breast carcinoma of no special type (IBC-NST) and to investigate, by comprehensive RNA sequencing analyses, the mechanisms involved in the heightened malignant potential of vimentin fKusZ.